Article
Inhibiting autophagy reduces retinal degeneration caused by protein misfolding.
Autophagy - 1 Jan 2018
Yao Jingyu, Qiu Yaoyan, Frontera Eric, Jia Lin, Khan Naheed W, Klionsky Daniel J, Ferguson Thomas A, Thompson Debra A, Zacks David N
Abstract excerpt
Mutations in the genes necessary for the structure and function of vertebrate photoreceptor cells are associated with multiple forms of inherited retinal degeneration. Mutations in the gene encoding RHO (rhodopsin) are a common cause of autosomal dominant retinitis pigmentosa (adRP), with the Pro23His variant of RHO resulting in a misfolded protein that activates endoplasmic reticulum stress and the unfolded...
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