Article

Ocular delivery of different VCP inhibitory formulations prevents retinal degeneration in rhodopsin 255 isoleucine deletion mice

2025-06-25

Abstract excerpt

Rhodopsin-mediated autosomal dominant retinitis pigmentosa ( RHO -adRP) is a progressive inherited retinal degenerative disorder currently lacking effective treatments. A recurrent 3-base pair deletion in the RHO gene, resulting in the loss of isoleucine at codon 255 or 256 ( RHO ΔI255 or RHO ΔI256 ), has been identified in patients from the United Kingdom, Germany, Belgium, China, and Korea, suggesting a broad...

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Literature Corpus work: 4ac72617-effe-5dd9-8197-ac1b473d4799
DOI: 10.1101/2025.06.25.661245

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