Article

Inhibition of VCP preserves retinal structure and function in autosomal dominant retinal degeneration

2020-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Due to continuously high production rates of rhodopsin (RHO) and high metabolic activity, photoreceptor neurons are especially vulnerable to defects in proteostasis. A proline to histidine substitution at position 23 (P23H) leads to production of structurally misfolded RHO, causing the most common form of autosomal dominant Retinitis Pigmentosa (adRP) in North America. The AAA-ATPase valosin-con...

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Literature Corpus work: 014a2859-698d-5744-bf72-16465c29828d
DOI: 10.1101/2020.11.17.384669

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