Article

Inhibiting LRRK2 kinase activity protects against the pathology associated with the presenilin 1 Ile416Thr mutation in cholinergic neurons

2025-09-19

Abstract excerpt

Familial Alzheimer’s disease (FAD) is an accelerated form of dementia that affects cholinergic neurons. Unfortunately, despite several efforts, no single drug or treatment has shown complete efficacy. Therefore, it is imperative to find effective therapeutic agents. Previously, it has been shown that the PSEN1 I416T variant induces FAD-like neuropathology in cholinergic-like neurons (ChLNs), which is characterized...

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Literature Corpus work: a63fab72-bc8a-53be-89c0-526b0607d367
DOI: 10.1101/2025.09.17.25336024

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