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Article

PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease

14 Sept 2017

Abstract excerpt

Mitochondrial dysfunction and synaptic damage are early pathological features of the Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a manifestation of brain pathologies such as accumulation of amyloid-β peptide and mitochondrial damage. The underlying pathogenic mechanisms and effective disease-modifying therapies for Alzheimer's disease remain elusive. Here, we demonstrate for...

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PMID: 29077793
DOI: 10.1093/brain/awx258

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