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Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson's Disease Dementia (PDD).

Neurotoxicity research - 6 Jun 2024

Giraldo-Berrio Daniela, Mendivil-Perez Miguel, Velez-Pardo Carlos, Jimenez-Del-Rio Marlene

Abstract excerpt

Parkinson's disease with dementia (PDD) is a neurological disorder that clinically and neuropathologically overlaps with Parkinson's disease (PD) and Alzheimer's disease (AD). Although it is assumed that alpha-synuclein ( α -Syn), amyloid beta (A β ), and the protein Tau might synergistically induce cholinergic neuronal degeneration, presently the pathological mechanism of PDD remains unclear. Therefore, it is...

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Identifiers

PMID: 38842585
DOI: 10.1007/s12640-024-00705-3
PMCID: PMC11156752

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