Article

Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans

2025-04-25

Abstract excerpt

Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linking mitochondrial genotypes and mitonuclear genetic interactions to phenotypes remains a complex challenge. Here, we have developed Caenorhabditis elegans as a model for mitonuclear epistasis studies. In a sample of 540 genetically distinct wild isolates, 10% of sites in th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6166349-245c-50eb-9d1f-a82174c887b8
DOI: 10.1101/2025.04.22.650036

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegansDOI 10.1101/2025.04.22.650036Read

Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Semantic proximity Read

A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance.Semantic proximity Read

A role for worm <i>cutl-24</i> in background- and parent-of-origin-dependent ER stress resistanceSemantic proximity Read

Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Semantic proximity Read

Mutant <i>C. elegans</i> mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generationsSemantic proximity Read

Dissecting the sequential evolution of a selfish mitochondrial genome in Caenorhabditis elegans.Semantic proximity Read

Compatibility between mitochondrial and nuclear genomes correlates with the quantitative trait of lifespan in Caenorhabditis elegans.Semantic proximity Read

C. elegans as a model to study mitochondrial biology and diseaseSemantic proximity Read

Mitochondrial-Nuclear Epistasis Impacts Fitness and Mitochondrial Physiology of Interpopulation Caenorhabditis briggsae Hybrids.Semantic proximity Read

Evolutionary Trajectories are Contingent on Mitonuclear Interactions.Semantic proximity Read

Mitochondrial DNA has strong selective effects across the nuclear genomeSemantic proximity Read

Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size.Semantic proximity Read