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Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.

Molecular biology and evolution - 28 Nov 2025

Nguyen Tuc H M, Klein Daniel A, Weklar Olivia S, Wengrow Erin R, Rockman Matthew V

Abstract excerpt

Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linking mitochondrial genotypes and mitonuclear genetic interactions to phenotypes remains a complex challenge. Here, we have developed Caenorhabditis elegans as a model for mitonuclear epistasis studies. In a sample of 540 genetically distinct wild isolates, 10% of sites in...

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Identifiers

PMID: 41367310
DOI: 10.1093/molbev/msaf300
PMCID: PMC12690269

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