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Article

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

25 Nov 2021

Abstract excerpt

Inflammatory Breast Cancer (IBC) is a highly aggressive malignancy with distinct clinical and histopathological features whose molecular basis is unresolved. Here we describe a human IBC cell line, A3250, that recapitulates key IBC features in a mouse xenograft model, including skin erythema, diffuse tumor growth, dermal lymphatic invasion, and extensive metastases. A3250 cells express very high levels of the...

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PMID: 34824220
DOI: 10.1038/s41467-021-27108-8

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