Article

RCN3 Drives Pathological Proliferation of KRT5 + Basaloid Cells and Fibrogenesis in IPF via the WNT/β-catenin Axis

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Introduction: In idiopathic pulmonary fibrosis (IPF), pathological expansion of dysfunctional KRT5⁺ basaloid cells is a hallmark of aberrant epithelial remodeling, but the molecular drivers of this dysregulation remain poorly defined. Objective We aimed to investigate whether and how Reticulocalbin 3 (RCN3) regulates the dysfunctional phenotype of KRT5⁺ cells in IPF. Methods Using pr...

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Literature Corpus work: a5eefbd0-b91b-5733-91ff-4d2544b71058
DOI: 10.21203/rs.3.rs-8489862/v1

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