Article

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

2024-06-06

Abstract excerpt

<h4>Rationale</h4> The role of MUC5B mucin expression in IPF pathogenesis is unknown. Bleomycin-exposed rodent models do not exhibit sustained fibrosis or airway remodeling. Unlike mice, ferrets have human-like distribution of MUC5B expressing cell types and natively express the risk-conferring variant that induces high MUC5B expression in humans. We hypothesized that ferrets would consequently exhibit aberrant r...

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Literature Corpus work: a5e796de-12d9-54ac-bf2f-6e59affa69f9
DOI: 10.1101/2024.06.04.597198

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