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Article

Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.

American journal of respiratory cell and molecular biology - 1 Apr 2023

Rodriguez Luis, Tomer Yaniv, Carson Paige, Dimopoulos Thalia, Zhao Ming, Chavez Katrina, Iyer Swati, Huang Li, Ebert Christina, Sereda Larisa, Murthy Aditi, Trujillo Glenda, Beers Michael F, Katzen Jeremy

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial lung disease. A barrier to developing more effective therapies for IPF is the dearth of preclinical models that recapitulate the early pathobiology of this disease. Intratracheal bleomycin, the conventional preclinical murine model of IPF, fails to reproduce the intrinsic dysfunction to the alveolar epithelial type 2 cell (AEC2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36473455
DOI: 10.1165/rcmb.2022-0203MA
PMCID: PMC10112421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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