Article

Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia

2021-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is pathologically classified by usual interstitial pneumonia (UIP). Conventional bleomycin models used to study pathogenic mechanisms of pulmonary fibrosis display transient inflammation and fibrosis so their relevance to UIP is limited. We developed a novel chronic i nduced-UIP (iUIP) model, inducing fibrosis in D1CC×D1BC transgenic mice by intra-tracheal in...

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Literature Corpus work: 297aae11-088a-56fc-b250-c79ccb6ba6c6
DOI: 10.1101/2021.03.18.435059

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