Airway disease phenotypes in animal models of cystic fibrosis.

Abstract excerpt

In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis, as well as the development and testing of potential therapeutics. However, recently generated CF animal models including rat, ferret and pig models demonstrate a...

Topics

• Animals
• Cystic Fibrosis
• Disease Models, Animal
• Ferrets
• Gene Knockout Techniques
• Humans
• Mice
• Phenotype
• Rats
• Swine