Article

The Old Genetically Heterogeneous Mouse Model Recapitulates Chronic and Persistent Idiopathic Pulmonary Fibrosis with Strong Senescence Signatures

2025-07-26

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive lung disease that primarily afflicts people over the age of 65. IPF is characterized by lung scarring, an elevated senescence burden, and interstitial pneumonia, resulting in disability and mortality. The growing aging population worldwide, limited effectiveness of current treatments, and high economic burden underscore the need for robust models to...

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Literature Corpus work: 35d1a2a8-9805-5715-8d66-40010828d2da
DOI: 10.1101/2025.07.22.665978

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