Article

Clioquinol improves catalytic activity of PHGDH and shows antiseizure efficacy in patients

2024-10-01

Abstract excerpt

Drug-resistant epilepsy (DRE) affects over 25 million people worldwide and is associated with neuroinflammation. We identified haloquinolines from a drug repurposing library as potent activators of phosphoglycerate dehydrogenase (PHGDH) enzyme, which converts 3-phosphoglycerate to generate serine and the neurotransmitter glycine, and steers anti-inflammatory responses. The most promising haloquinoline clioquinol c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5e33ef8-63c7-5866-a3d3-ef4134348ded
DOI: 10.1101/2024.09.28.24314470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clioquinol improves catalytic activity of PHGDH and shows antiseizure efficacy in patientsDOI 10.1101/2024.09.28.24314470Read

Drug repositioning in epilepsy reveals novel antiseizure candidatesSemantic proximity Read

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignSemantic proximity Read

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignSemantic proximity Read

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsySemantic proximity Read

An <i>in vivo</i> drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiencySemantic proximity Read

Drug Repurposing and Lysosomal Storage Disorders: A Trick to Treat.Semantic proximity Read

Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids.Semantic proximity Read

Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS contract site for the Epilepsy Therapy Screening ProgramSemantic proximity Read

Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency.Semantic proximity Read

<i>In-silico</i> Drug Repurposing Pipeline for Epilepsy: Integrating Deep Learning and Structure-based ApproachesSemantic proximity Read

Schizophrenia and psychosis-related disorders: how the glutamate hypothesis contributes to the onset of the mental illnessSemantic proximity Read

Deaminase Modulation Driving a New Era in Drug DevelopmentSemantic proximity Read