Article

Mitigation of Stress-induced Structural Remodeling and Functional Deficiency in iPSC-CMs with PLN R9C Mutation by Promoting Autophagy

2024-04-17

Abstract excerpt

<h4>Background</h4> Phospholamban (PLN) is a key regulator of cardiac function connecting adrenergic signaling and calcium homeostasis. The R9C mutation of PLN is known to cause early onset dilated cardiomyopathy (DCM) and premature death, yet the detailed mechanisms underlie the pathologic remodeling process are not well defined in human cardiomyocytes. The aim of this study is to unravel the role of PLN R9C in...

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Literature Corpus work: 69aee205-02d1-54d8-ac12-9f707bb9214c
DOI: 10.1101/2024.04.17.589921

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