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Article

Human MeCP2 binds to promoters and inhibits transcription in an unmethylated yeast genome.

Genetics - 3 Sept 2025

Brown Joshua A R, Ling Maggie Y M, Ausió Juan, Howe LeAnn J

Abstract excerpt

MeCP2 is a DNA-binding transcriptional regulator that is present at near-histone levels in mammalian cortical neurons. Originally identified as a DNA methylation reader, MeCP2 has been proposed to repress transcription by recruiting corepressors to methylated DNA. While some genome-wide occupancy studies support a preference for methylated DNA, others suggest that MeCP2 binding is more influenced by DNA sequence...

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DNA Methylation
Genome, Fungal
Methyl-CpG-Binding Protein 2
Promoter Regions, Genetic
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Transcription, Genetic

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Identifiers

PMID: 40101152
DOI: 10.1093/genetics/iyaf043
PMCID: PMC12406007

Genes

GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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