Article
Rett syndrome: a surprising result of mutation in MECP2.
Human molecular genetics - 1 Oct 2000
Dragich J, Houwink-Manville I, Schanen C
Abstract excerpt
The identification of mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) in Rett syndrome represents a major advance in the field. The current model predicts that MeCP2 represses transcription by binding methylated CpG residues and mediating chromatin remodeling. A physical interaction between MeCP2, histone deacetylases and the transcriptional co-repressor Sin3A has been demonstrated, as well as...
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