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Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

2023-03-03

Abstract excerpt

Low back pain (LBP) is often associated with the degeneration of human intervertebral discs (IVDs). However, the pain-inducing mechanism in degenerating discs remains to be elucidated. Here, we identified a subtype of locally residing nucleus pulposus cells (NPCs), generated by the environmental stress in degenerating discs, that triggered the onset of discogenic LBP. Single-cell transcriptomic analysis of human t...

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Identifiers and source

Literature Corpus work
a57854ec-e95d-55d2-be53-a9917fe04e94
DOI
10.1101/2023.03.02.530506
Open publication

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Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back painDOI 10.1101/2023.03.02.530506
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