Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes

3 Jan 2024

Abstract excerpt

BACKGROUND: Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degeneration are well documented, the phenotype and functions of the resident CEP cells are critically understudied. To better characterize CEP cell phenotype and possible mechanisms of CEP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical and Thoracic Myelopathy
Share to Osteoarthritis Treatment and Mechanisms
Share to Spine and Intervertebral Disc Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38173036
DOI: 10.1186/s13075-023-03220-6

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypesPMID 38173036Read ↗

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degenerationSemantic proximity Read ↗

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degenerationSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular InteractionsSemantic proximity Read ↗

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discsSemantic proximity Read ↗

Single-cell sequencing: New insights for intervertebral disc degenerationSemantic proximity Read ↗

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration ProgressionSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc DegenerationSemantic proximity Read ↗

Revealing the Key MSCs Niches and Pathogenic Genes in Influencing CEP Homeostasis: A Conjoint Analysis of Single-Cell and WGCNASemantic proximity Read ↗

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progressionSemantic proximity Read ↗

Single-cell RNA-sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis.Semantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc DegenerationSemantic proximity Read ↗

Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.