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Changes in nucleus pulposus cell atlas and the role of SPP1 during intervertebral disc degeneration: Single-cell sequencing analysis

2024-08-21

Abstract excerpt

<title>Abstract</title> <p>Background The nucleus pulposus (NP) plays a central role in the pathogenesis of intervertebral disc degeneration (IVDD); however, its internal cellular heterogeneity and molecular mechanisms have not yet been elucidated. Methods ScRNA-seq was used to evaluate the structure of the NP at different degenerative stages in the same individual with IVDD. Unsupervised clustering of cells ba...

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Literature Corpus work
bc5071e5-26d3-5f1a-90e8-c025f66dc3d9
DOI
10.21203/rs.3.rs-4737330/v1
Open publication

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