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Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).

International journal of oncology - 1 May 2026

Aloliqi Abdulaziz A, Alnuqaydan Abdullah M, Alshebremi Mohammad, Rahmani Arshad Husain, Khan Amjad Ali

Abstract excerpt

Pancreatic cancer, predominantly manifested as pancreatic ductal adenocarcinoma (PDAC), is a highly aggressive malignancy in which the dysregulated crosstalk between Kirsten rat sarcoma viral oncogene homolog (KRAS) and microRNAs (miRNAs) plays a critical role. It is one of the leading causes of cancer‑related mortality worldwide, with its global incidence more than doubling over the past 25 years. PDAC is...

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Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
Gene Expression Regulation, Neoplastic
MicroRNAs
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Signal Transduction

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Open in PubMed Open full text

Identifiers

PMID: 41860028
DOI: 10.3892/ijo.2026.5873
PMCID: PMC13038340

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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