Article
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008
Kimmelman Alec C, Hezel Aram F, Aguirre Andrew J, Zheng Hongwu, Paik Ji-Hye, Ying Haoqiang, Chu Gerald C, Zhang Jean X, Sahin Ergun, Yeo Giminna, Ponugoti Aditya, Nabioullin Roustem, Deroo Scott, Yang Shenghong, Wang Xiaoxu, McGrath John P, Protopopova Marina, Ivanova Elena, Zhang Jianhua, Feng Bin, Tsao Ming S, Redston Mark, Protopopov Alexei, Xiao Yonghong, Futreal P Andrew, Hahn William C, Klimstra David S, Chin Lynda, DePinho Ronald A
Abstract excerpt
Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with intrinsic resistance to standard therapies and genome instability, are major contributors to poor long-term survival. The genetic elements governing the invasive propensity of PDAC have not been well elucidated. Here, in the course of validating resident...
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