Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation

7 Mar 2019

Abstract excerpt

Previously, we established a microRNA (miRNA) expression signature in pancreatic ductal adenocarcinoma (PDAC) tissues using RNA sequencing and found significantly reduced expression of miR-204-5p. Here, we aimed to investigate the functional significance of miR-204-5p and to identify miR-204-5p target genes involved in PDAC pathogenesis. Cancer cell migration and invasion were significantly inhibited by ectopic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MicroRNA in disease regulation
Share to Pancreatic and Hepatic Oncology Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30866526
DOI: 10.3390/cancers11030327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 RegulationPMID 30866526Read ↗

RhoV Promotes Proliferation, Migration, and MAPK Activation in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic GenesSemantic proximity Read ↗

LncRNA LINC00941 Links Oncogenic KRAS Signaling to Aggressiveness and Chemoresistance in Pancreatic CancerSemantic proximity Read ↗

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencingSemantic proximity Read ↗

Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expressionSemantic proximity Read ↗

RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancerSemantic proximity Read ↗

Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathwaySemantic proximity Read ↗

Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysisSemantic proximity Read ↗

Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancerSemantic proximity Read ↗

Dysregulation of miRNAs Targeting the IGF-1R Pathway in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.