Article

Hypoxia-tolerant vascular endothelial growth factor-A (VEGF-A) and the genetic variations of <i>VEGFA</i> in Sherpa highlanders

2020-03-16

Abstract excerpt

Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, partly by one of the adaptation mechanisms promoting increases of microcirculatory blood flow and capillary density at high altitude for restoring oxygen supply to tissues. Hypoxia stimulates vascular endothelial growth factor (VEGF), which is an important signaling protein involved in hypoxia-stimulated vasculogenesis and angioge...

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Literature Corpus work: a5235960-a74f-5697-bedc-d65e24548219
DOI: 10.1101/2020.03.16.993568

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