Genetic and immune changes in Tibetan high-altitude populations contribute to biological adaptation to hypoxia.

doi:10.1265/ehpm.22-00040

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Article

Genetic and immune changes in Tibetan high-altitude populations contribute to biological adaptation to hypoxia.

Environmental health and preventive medicine - 1 Jan 2022

Bai Jun, Li Lijuan, Li Yanhong, Zhang Liansheng

Abstract excerpt

BACKGROUND: Tibetans have lived at very high altitudes for thousands of years, and have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. Expanding awareness and knowledge of the differences in hematology, hypoxia-associated genes, immune system of people living at different altitudes and from different ethnic groups may provide evidence for the prevention of mountain...

Topics

Adaptation, Biological
Altitude
Altitude Sickness
Basic Helix-Loop-Helix Transcription Factors
CD8-Positive T-Lymphocytes
Chemokine CCL4
Hemoglobins
Humans
Hypoxia
Hypoxia-Inducible Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypoxia-Inducible Factor-Proline Dioxygenases

Interleukin-8

Polymorphism, Single Nucleotide

Receptor, ErbB-2

Receptors, Tumor Necrosis Factor, Type II

Thrombomodulin

Tibet

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Identifiers

PMID: 36244759
DOI: 10.1265/ehpm.22-00040
PMCID: PMC9640738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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