Article
Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas.
High altitude medicine & biology - 1 Jan 2006
Droma Yunden, Hanaoka Masayuki, Basnyat Buddha, Arjyal Amit, Neupane Pritam, Pandit Anil, Sharma Dependra, Miwa Naoyuki, Ito Michiko, Katsuyama Yoshihiko, Ota Masao, Kubo Keishi
Abstract excerpt
The Sherpas' adaptation to high altitude has been hypothesized as being due to a genetic basis since the beginning of the last century, but this has yet to be demonstrated. We randomly enrolled 105 Sherpas in Namche Bazaar (3440 m) and 111 non-Sherpa Nepalis in Kathmandu (1330 m) in Nepal. The genotypes of Glu298Asp and eNOS4b/a polymorphisms of the endothelial nitric oxide synthase (eNOS) gene were identified....
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