Article

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

2021-02-18

Abstract excerpt

Cortical processing depends on finely-tuned excitatory and inhibitory connections in neuronal microcircuits. Reduced inhibition by somatostatin-expressing interneurons is a key component of altered inhibition associated with treatment-resistant major depressive disorder (depression), which is implicated in cognitive deficits and rumination, but the link remains to be better established mechanistically in humans. H...

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Literature Corpus work: a51c2ac3-4092-5fde-bedc-c88f9beeae49
DOI: 10.1101/2021.02.17.431698

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