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Article

The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder.

Neuroscience and biobehavioral reviews - 1 Oct 2011

Northoff Georg, Wiebking Christine, Feinberg Todd, Panksepp Jaak

Abstract excerpt

Major depressive disorder (MDD) has traditionally been characterized by various psychological symptoms, involvement of diverse functional systems (e.g., somatic, affect, cognition, reward, etc.), and with progress in neuroscience, an increasing number of brain regions. This has led to the general assumption that MDD is a stress-responsive brain 'system disorder' where either one or several alterations infiltrate...

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Identifiers

PMID: 21192971
DOI: 10.1016/j.neubiorev.2010.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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