Article

The central renin angiotensin II system – a genetic pathway, functional decoding and selective target engagement characterization in humans

2023-03-21

Abstract excerpt

The brain renin angiotensin II system plays a pivotal role in cognition and neuropathology via the central angiotensin II type 1 receptor (AT1R), yet the lack of a biologically informed framework currently impedes translational and therapeutic progress. We combined imaging transcriptomic and meta-analyses with pharmaco-resting state fMRI employing a selective AT1R antagonist in a discovery-replication design (n=13...

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Literature Corpus work: 44ab28b7-d699-5f1c-bceb-506313881c9d
DOI: 10.1101/2023.03.20.533428

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