Article

Testing the Hypothesis of Habenula Hyperactivity in Depression: A Study Using Fractional Amplitude of Low-Frequency Fluctuation (fALFF)

2026-07-16

Abstract excerpt

<p>Background: The habenula, a key regulator of aversive processing, has been consistently implicated in animal models of depression, where elevated baseline activity is a robust and reproducible finding. This has led to the widely discussed hypothesis that habenula hyperactivity contributes to the pathophysiology of major depressive disorder (MDD). However, whether this hyperactivity is present in human depressio...

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Literature Corpus work: 7875eee5-1790-5abe-8f25-72f5dc93cbda
DOI: 10.31234/osf.io/9pk53_v1

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