Article

Interplay of Cullin5-HECTD3 ubiquitin ligases regulates stability of CRAF mutant associated with hypertrophy

2026-05-27

Abstract excerpt

Proteostatic imbalance caused by CRAF (Raf1) kinase mutation alters MAPK signaling and contributes to RASopathies. CRAF proteostasis is maintained by chaperones, Hsp90 which aids in folding, maturation, and activation; whereas Hsp70 recruits ubiquitin ligase CHIP for proteasomal degradation. However, the proteostasis of disease-associated CRAF mutants remains undefined. Here, we identify HECTD3, a HECT-ubiquitin l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5160c70-991b-5aca-bcb6-135c8269ba54
DOI: 10.64898/2026.05.23.727451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Interplay of Cullin5-HECTD3 ubiquitin ligases regulates stability of CRAF mutant associated with hypertrophyDOI 10.64898/2026.05.23.727451Read

The Role of HECT-Type E3 Ligase in the Development of Cardiac DiseaseSemantic proximity Read

Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradationSemantic proximity Read

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.Semantic proximity Read

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.Semantic proximity Read

Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.Semantic proximity Read

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9ASemantic proximity Read

p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and DysfunctionSemantic proximity Read

Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants.Semantic proximity Read