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Article

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.

The EMBO journal - 1 Feb 2025

Hao Xiaoyan, Hu Zhengwei, Li Mengjie, Zhang Shuo, Tang Mibo, Hao Chenwei, Qi Shasha, Liang Yuanyuan, Almeida Michael F, Smith Kaitlan, Zuo Chunyan, Feng Yanmei, Guo Mengnan, Ma Dongrui, Li Shuangjie, Wang Zhiyun, Sun Yuemeng, Deng Zhifen, Mao Chengyuan, Xia Zongping, Jiang Yong, Gao Yanxia, Xu Yuming, Schisler Jonathan C, Shi Changhe

Abstract excerpt

The carboxyl terminus of Hsc70-interacting protein (CHIP) is pivotal for managing misfolded and aggregated proteins via chaperone networks and degradation pathways. In a preclinical rodent model of CHIP-related ataxia, we observed that CHIP mutations lead to increased levels of phosphodiesterase 9A (PDE9A), whose role in this context remains poorly understood. Here, we investigated the molecular mechanisms...

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Identifiers

PMID: 39806097
DOI: 10.1038/s44318-024-00351-7
PMCID: PMC11833080

Genes

PDE9A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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