Article
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
Molecular cell - 26 Sept 2008
Noble Catherine, Mercer Kathryn, Hussain Jahan, Carragher Linda, Giblett Susan, Hayward Robert, Patterson Cam, Marais Richard, Pritchard Catrin A
Abstract excerpt
The CRAF protein kinase regulates proliferative, differentiation, and survival signals from activated RAS proteins to downstream effectors, most often by inducing MEK/ERK activation. A well-established model of CRAF regulation involves RAS-mediated translocation of CRAF to the plasma membrane, where it is activated by a series of events including phosphorylation. Here we have discovered a new mode of regulation...
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