Article
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
Molecular cell - 26 Sept 2008
Noble Catherine, Mercer Kathryn, Hussain Jahan, Carragher Linda, Giblett Susan, Hayward Robert, Patterson Cam, Marais Richard, Pritchard Catrin A
Abstract excerpt
The CRAF protein kinase regulates proliferative, differentiation, and survival signals from activated RAS proteins to downstream effectors, most often by inducing MEK/ERK activation. A well-established model of CRAF regulation involves RAS-mediated translocation of CRAF to the plasma membrane, where it is activated by a series of events including phosphorylation. Here we have discovered a new mode of regulation...
Topics
- Animals
- Enzyme Activation
- Enzyme Stability
- Fibroblasts
- Mice
- Models, Biological
- Phenotype
- Phosphorylation
- Phosphoserine
- Proteasome Endopeptidase Complex
- Protein Folding