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Article

Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants.

Cardiovascular research - 1 Apr 2005

Sarikas Antonio, Carrier Lucie, Schenke Carolus, Doll Daniela, Flavigny Jeanne, Lindenberg Katrin S, Eschenhagen Thomas, Zolk Oliver

Abstract excerpt

OBJECTIVE: Most cardiac myosin binding protein C (cMyBP-C) gene mutations causing familial hypertrophic cardiomyopathy (FHC) result in C-terminal truncated proteins. However, truncated cMyBP-Cs were undetectable in myocardial tissue of FHC patients. In the present study, we investigated whether truncated cMyBP-Cs are subject to accelerated degradation by the lysosome or ubiquitin-proteasome system (UPS). METHODS...

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Source

Identifiers

PMID: 15769446
DOI: 10.1016/j.cardiores.2005.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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