Article

Cancer Associated Fibroblast (CAF) regulation of PDAC parenchymal (CPC) and CSC phenotypes is modulated by ECM composition.

2020-02-20

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all cancers having one of the lowest five-year survival rates. One of its hallmarks is a dense desmoplastic stroma consisting in the abnormal accumulation of extracellular matrix (ECM) components, especially Collagen I. This highly fibrotic stroma embeds the bulk cancer (parenchymal) cells (CPCs), cancer stem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5100fbd-cb62-5d38-8273-65468a620a70
DOI: 10.21203/rs.2.13193/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cancer Associated Fibroblast (CAF) regulation of PDAC parenchymal (CPC) and CSC phenotypes is modulated by ECM composition.DOI 10.21203/rs.2.13193/v2Read

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM CompositionSemantic proximity Read

Fibroblast Heterogeneity in the Pancreatic Tumor MicroenvironmentSemantic proximity Read

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinomaSemantic proximity Read

A tumor microenvironment integrated (TMI) staging system for pancreatic ductal adenocarcinoma based on cancer-associated fibroblast and molecular consensus signaturesSemantic proximity Read

Stromal biology of pancreatic cancerSemantic proximity Read

Pancreatic Fibroblast Heterogeneity: From Development to CancerSemantic proximity Read

Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and CollagenSemantic proximity Read

Pancreatic Cancer and Its Microenvironment-Recent Advances and Current Controversies.Semantic proximity Read

Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal FibroblastsSemantic proximity Read

Adipose‐derived mesenchymal stem cells differentiate into pancreatic cancer‐associated fibroblasts in vitroSemantic proximity Read

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic ResistanceSemantic proximity Read