Back to search

Article

A tumor microenvironment integrated (TMI) staging system for pancreatic ductal adenocarcinoma based on cancer-associated fibroblast and molecular consensus signatures

2026-01-30

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid tumor with poor prognosis. Existing prognostication systems rely on clinical staging, but systems of tumor classification through molecular signatures and the association between cancer-associated fibroblast (CAF) subtypes and clinical outcomes suggest that prognostic systems could be improved by integrating thes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6e706e98-ba11-5e8e-b1bb-e5074cbf8aad
DOI
10.21203/rs.3.rs-8532623/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A tumor microenvironment integrated (TMI) staging system for pancreatic ductal adenocarcinoma based on cancer-associated fibroblast and molecular consensus signaturesDOI 10.21203/rs.3.rs-8532623/v1
Tumor-intrinsic and Cancer-associated Fibroblast Subtypes Independently Predict Outcomes in Pancreatic CancerSemantic proximity
Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity
Bulk RNA sequencing deconvolution of pancreatic ductal adenocarcinoma identifies cancer-associated fibroblast subsets associated with survival and tumor microenvironment compositionSemantic proximity
Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity
Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDACSemantic proximity
Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and CollagenSemantic proximity
A MyCAF-Based Signature for Prognosis, Immune Landscape, and Therapeutic Response in Pancreatic CancerSemantic proximity
BNIP3 + cancer-associated fibroblasts and their associated genes are accelerators of pancreatic cancerSemantic proximity
Molecular classification and prognosis study of pancreatic ductal adenocarcinoma through multi-omics integrated clustering analysis.Semantic proximity
Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity
The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer‐associated fibroblast subtypesSemantic proximity
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progressionSemantic proximity
Select a neighboring publication to make it the new centre.