Article

False positives in trans-eQTL and co-expression analyses arising from RNA-sequencing alignment errors

2019-04-08

Abstract excerpt

Sequence similarity among distinct genomic regions can lead to errors in alignment of short reads from next-generation sequencing. While this is well known, the downstream consequences of misalignment have not been fully characterized. We assessed the potential for incorrect alignment of RNA-sequencing reads to cause false positives in both gene expression quantitative trait locus (eQTL) and co-expression analyse...

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Literature Corpus work: a4fb7774-42d5-539e-bb0e-20b63e7c57a3
DOI: 10.12688/f1000research.17145.2

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