Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".

Science (New York, N.Y.) - 16 Mar 2012

Pickrell Joseph K, Gilad Yoav, Pritchard Jonathan K

Abstract excerpt

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported more than 10,000 mismatches between messenger RNA and DNA sequences from the same individuals, which they attributed to previously unrecognized mechanisms of gene regulation. We found that at least 88% of these sequence mismatches can likely be explained by technical artifacts such as errors in mapping sequencing reads to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Genetic Variation
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 22422963
DOI: 10.1126/science.1210484
PMCID: PMC5207799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".PMID 22422963Read ↗

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".Semantic proximity Read ↗

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".Semantic proximity Read ↗

RNA-DNA sequence differences spell genetic code ambiguities.Semantic proximity Read ↗

Analysis of human mRNAs with the reference genome sequence reveals potential errors, polymorphisms, and RNA editing.Semantic proximity Read ↗

Widespread RNA and DNA sequence differences in the human transcriptome.Semantic proximity Read ↗

Thousands of large-scale RNA sequencing experiments yield a comprehensive new human gene list and reveal extensive transcriptional noiseSemantic proximity Read ↗

Illuminating the dark side of the human transcriptome with long read transcript sequencingSemantic proximity Read ↗

Systematic investigation of insertional and deletional RNA-DNA differences in the human transcriptome.Semantic proximity Read ↗

Human gene function publications that describe wrongly identified nucleotide sequence reagents are unacceptably frequent within the genetics literatureSemantic proximity Read ↗

Towards a reference genome that captures global genetic diversity.Semantic proximity Read ↗

Recovery of non-reference sequences missing from the human reference genomeSemantic proximity Read ↗

Genomic variations in non-coding RNAs: Structure, function and regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.