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Article

Consistent RNA sequencing contamination in GTEx and other data sets.

Nature communications - 22 Apr 2020

Nieuwenhuis Tim O, Yang Stephanie Y, Verma Rohan X, Pillalamarri Vamsee, Arking Dan E, Rosenberg Avi Z, McCall Matthew N, Halushka Marc K

Abstract excerpt

A challenge of next generation sequencing is read contamination. We use Genotype-Tissue Expression (GTEx) datasets and technical metadata along with RNA-seq datasets from other studies to understand factors that contribute to contamination. Here we report, of 48 analyzed tissues in GTEx, 26 have variant co-expression clusters of four highly expressed and pancreas-enriched genes (PRSS1, PNLIP, CLPS, and/or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32321923
DOI: 10.1038/s41467-020-15821-9
PMCID: PMC7176728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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