Article

<i>ST6GAL1</i> -mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia

2020-04-29

Abstract excerpt

Heterogeneity in phenotypes of malignantly transformed cells and aberrant glycan expression on their surface are two prominent hallmarks of cancers that have hitherto not been linked to each other. In this paper, we identify heterogeneity in a specific glycan linkage: α2,6-linked sialic acids within breast cancer cells in vivo and in culture. Upon sorting out two populations with moderate and relatively higher ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4fabfe9-665b-5abd-a0cf-394c7a4aae5a
DOI: 10.1101/2020.04.28.065573

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>ST6GAL1</i> -mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epitheliaDOI 10.1101/2020.04.28.065573Read

α2-6–Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation <i>In vivo</i>Semantic proximity Read

Tumor sialylation controls effective anti-cancer immunity in breast cancerSemantic proximity Read

Cancer-associated hypersialylated MUC1 drives the differentiation of monocytes into macrophages with a pathogenic phenotypeSemantic proximity Read

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read

Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesionSemantic proximity Read

CyTOF-Lec: Single-cell Glycomics Analysis Reveals Glycan Features Defining Cells Differentially Susceptible to HIVSemantic proximity Read

Regulation of the metastatic cell phenotype by sialylated glycans.Semantic proximity Read

Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity.Semantic proximity Read

An <i>In Vivo</i> Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis SuppressorSemantic proximity Read

GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells InteractomeSemantic proximity Read

Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype.Semantic proximity Read

Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.Semantic proximity Read