Article

Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer

2023-07-10

Abstract excerpt

<h4>Background: </h4> Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells. In particular, the authors have reported differences in sphingolipid content in colorectal cancer tissues. The associations among genetic mutations, clinicopathologi...

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Literature Corpus work: a4d8ba75-2532-5e3a-b22c-5d9d225ecc68
DOI: 10.21203/rs.3.rs-3098987/v1

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