Article
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.
Cell death & disease - 6 Oct 2021
Li Rui, Hao Yanyu, Wang Qiuhan, Meng Yuan, Wu Kunhe, Liu Chaoqun, Xu Lijun, Liu Ziguang, Zhao Liang
Abstract excerpt
Sphingolipid metabolic dysregulation has increasingly been considered to be a drug-resistance mechanism for a variety of tumors. In this study, through an LC-MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer (CRC). Gain- and...
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