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Article

Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer.

Scientific reports - 27 Sept 2023

Hayama Tamuro, Hama Kotaro, Ozawa Tsuyoshi, Fujiwara Yuko, Nozawa Keijiro, Matsuda Keiji, Yokoyama Kazuaki, Hashiguchi Yojiro, Ochiai Hiroki, Misawa Takeyuki, Fukagawa Takeo

Abstract excerpt

Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells. In particular, the authors have reported differences in sphingolipid content in colorectal cancer tissues. The associations among genetic mutations, clinicopathological factors, and...

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Identifiers

PMID: 37758931
DOI: 10.1038/s41598-023-43557-1
PMCID: PMC10533536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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