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Genetically proxied inhibition of L-2-hydroxyglutarate dehydrogenase and the risk of coronary artery disease: A Mendelian randomization study

2023-01-17

Abstract excerpt

<h4>Background</h4> L-2-hydroxyglutarate dehydrogenase (L2HGDH) deletion-induced L-2-hydroxyglutarate accumulation plays a cardioprotective role in hypoxic conditions. However, there has been no causal evidence in real-world clinical data. We aimed to examine the causal effects of L2HGDH inhibition on coronary artery disease (CAD) and myocardial infarction (MI) using Mendelian randomization (MR) analysis. <h4>Meth...

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Literature Corpus work
a4ce10bc-5f0a-5c8c-b243-cffc29a76625
DOI
10.1101/2023.01.15.23284550
Open publication

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Genetically proxied inhibition of L-2-hydroxyglutarate dehydrogenase and the risk of coronary artery disease: A Mendelian randomization studyDOI 10.1101/2023.01.15.23284550
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