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Article

Effects of uric acid on ischemic diseases, stratified by lipid levels: a drug-target, nonlinear Mendelian randomization study.

Scientific reports - 16 Jan 2024

Kim Jungeun, Lee Sun Yeop, Lee Jihye, Yoon Sanghyuk, Kim Eun Gyo, Lee Eunbyeol, Kim Nayoung, Lee Sol, Gym Ho, Park Sang-In

Abstract excerpt

Although uric acid-lowering agents such as xanthine oxidase inhibitors have potential cardioprotective effects, studies on their use in preventing cardiovascular diseases are lacking. We investigated the genetically proxied effects of reducing uric acid on ischemic cardiovascular diseases in a lipid-level-stratified population. We performed drug-target Mendelian randomization (MR) analyses using UK Biobank data...

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Share to Cerebral Infarction
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38228698
DOI: 10.1038/s41598-024-51724-1
PMCID: PMC10791707

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