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B7-H3 Modulates Cell Adhesion and Immune Evasion to Promote Tumor Progression and Natural Killer Cell Resistance in Hepatocellular Carcinoma

2026-03-31

Abstract excerpt

B7-H3 (CD276) is an immune checkpoint molecule frequently overexpressed in hepatocellular carcinoma (HCC) and represents a promising therapeutic target. However, its roles in tumor cell adhesion, metastatic behavior and immune evasion—particularly in interactions with natural killer (NK) cells—remain incompletely understood. In the present study, B7-H3 was depleted using small interfering RNA and CRISPR/Cas9 in ep...

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Literature Corpus work
a4be20cb-1794-5212-aedf-55cb6af514be
DOI
10.64898/2026.03.28.714951
Open publication

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B7-H3 Modulates Cell Adhesion and Immune Evasion to Promote Tumor Progression and Natural Killer Cell Resistance in Hepatocellular CarcinomaDOI 10.64898/2026.03.28.714951
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