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Article

Single-cell landscape of idiopathic multicentric Castleman disease in identical twins

3 Jan 2024

Abstract excerpt

ABSTRACT: Idiopathic multicentric Castleman disease (iMCD) is a rare cytokine-driven disorder characterized by systemic inflammation, generalized lymphadenopathy, and organ dysfunction. Here, we present an unusual occurrence of iMCD in identical twins and examined the immune milieu within the affected lymphoid organs and the host circulation using multiomic high-dimensional profiling. Using spatial enhanced...

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PMID: 38170173
DOI: 10.1182/blood.2023021992

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