Article

Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine Pathways

2024-09-11

Abstract excerpt

Castleman disease (CD) is inflammatory lymphoproliferative disorder of unclear etiology. To determine the cellular and molecular basis of CD, we analyzed the spatial proteome of 4,485,009 single cells, transcriptome of 50,117 single nuclei, immune repertoire of 8187 single nuclei, and pathogenic mutations in Unicentric CD, idiopathic Multicentric CD, HHV8-associated MCD, and reactive lymph nodes. CD was characteri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f47a3b6-a99a-5b26-bf16-fe0c36e830ec
DOI: 10.1101/2024.09.09.609717

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine PathwaysDOI 10.1101/2024.09.09.609717Read

Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathwaysSemantic proximity Read

Castleman Disease: Updated Pathophysiology, Diagnostic Approach and Therapeutic StrategiesSemantic proximity Read

Single-cell landscape of idiopathic multicentric Castleman disease in identical twinsSemantic proximity Read

Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the ACCELERATE registrySemantic proximity Read

Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related diseaseSemantic proximity Read

The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomicsSemantic proximity Read

Recurrent PDGFRB mutations in unicentric Castleman diseaseSemantic proximity Read

Idiopathic Multicentric Castleman Disease in Children: A Single-Center Retrospective AnalysisSemantic proximity Read

Dysregulated lymphocyte localization in idiopathic multicentric Castleman diseaseSemantic proximity Read

Single-cell RNA-seq analysis reveals aberrant CSF1 expression in disease-causing synovial fibroblasts of pigmented villonodular synovitisSemantic proximity Read

Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19Semantic proximity Read

Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet’s DiseaseSemantic proximity Read